• Home
  • Editorial Board
  • Articles
    • Editorials
    • Guest Articles
  • News
    • Featured
    • Biotech News
  • Interviews
    • Interviews – Academia
    • Interviews – Industry
  • Issues – Archives
  • Subscribe
  • Contact
Facebook Twitter Instagram
Trending
  • Special Issue-Exclusive coverage of BRIC-NIAB
  • India’s Rare Disease updates by Prof. Ramaiah Muthyala
  • Indian Scientists published positive results of first in nation ‘Hemophilia A’ gene therapy
  • Unlocking the Potential: Microalgae as a Sustainable Aquafeed Ingredient
  • Indian scientists developed World’s only farmers’ suit “Kisan Kavach” which can protect them from harmful pesticides
  • 3 Nobel Prizes in 2024 went to biotech and allied scientists
  • USFDA approves Biocon Biologics’ biosimilar for Crohn’s disease, psoriasis
  • Dr. Soumya Swaminathan Honored with FABA Lifetime Achievement Award for Contributions to Global Health
Saturday, May 31
Facebook Twitter Instagram LinkedIn
Biotech Express
  • Home
  • Editorial Board
  • Articles
    • Editorials
    • Guest Articles
  • News
    • Featured
    • Biotech News
  • Interviews
    1. Interviews – Academia
    2. Interviews – Industry
    Featured
    04/01/20241

    Interview: Reach to common man is the heart and soul of India International Science Festival- Dr. Arvind C Ranade Chief Coordinator, IISF- 2023

    Recent
    04/01/2024

    Interview: Reach to common man is the heart and soul of India International Science Festival- Dr. Arvind C Ranade Chief Coordinator, IISF- 2023

    22/05/2023

    Prof Rajeev Varshney becomes the 4th Indian Agricultural Scientist to be elected as Fellow of the Royal Society

    26/07/2022

    We are making best hygiene solutions through Biotech applications: Dr Rachna Dave, founder MicroGO

  • Issues – Archives
  • Subscribe
  • Contact
Biotech Express
You are at:Home»Biotech News»News-Industry»Scientists develop novel radiotracer for earlier detection of disease

Scientists develop novel radiotracer for earlier detection of disease

0
By Biotech Express on 19/02/2024 News-Industry, News-Research

The vast majority of positron emission tomography (PET) imaging systems map out how the body uses a radioactive form of glucose for energy. Since many cancers use glucose as metabolic fuel, they light up on glucose PET scans. However, not all cancers use glucose as fuel, and some normal organs, like the brain and heart, use high amounts of glucose too, making it difficult to identify some diseases from this type of diagnostic scan.

Now, scientists at the University of Ottawa (uOttawa) have developed a new radiotracer (called [18F]4-FDF) that can map how cells use fructose for energy. Fructose is a different type of metabolic fuel that is increasingly being recognized as a fuel for disease. Fructose, a monosaccharide known as “fruit sugar,” is a common dietary sugar found naturally in fruit, honey, and processed foods. Unlike glucose, fructose is not normally used for fuel by the healthy brain and heart, appearing mostly in healthy liver and kidneys. By identifying where fructose is being used in the body, [18F]4-FDF will allow for earlier detection of a wide range of diseases, including cancers, as well as inflammation of the heart and brain.

The research was conducted in the Molecular Medicine Lab at uOttawa under Associate Professor Adam Shuhendler from uOttawa’s Faculty of Science, who is also a scientist at the University of Ottawa Heart Institute, in collaboration with uOttawa professors Robert Ben and Christina Addison. Lead author Alexia Kirby, who is a doctoral student in biology, was responsible for validating and testing the radiotracer across various cell and animal models, while Nicholas Calvert, a doctoral student in chemistry and biomolecular sciences, used carbon isotope labeling to determine the metabolic pathway of the radiotracer in cells. The synthetic chemistry was developed by colleagues Rob Ben, Thomas Charlton, and Mojmir Suchy, while Dominic Graf and Mojmir Suchy handled the radiochemistry.

“For the first time, we can see where fructose, a common dietary sugar, is used in the body. Outside of the kidneys and the liver, fructose metabolism in any other organs may point to a sinister problem including cancer and inflammation,” explains Professor Shuhendler.

The [18F]4-FDF compound is made of a carefully modified form of fructose that incorporates a radioactive fluorine atom at a key chemical position, allowing researchers to track where and how much fructose is metabolized in our bodies. Through imaging with a PET camera, a tool that is routinely used in diagnostic imaging, observers can see the increased fructose used by malfunctioning organs and tissues, providing early indications of inflammation.

Journal Reference:

Alexia Kirby, Dominic Graf, Mojmír Suchý, Nicholas D. Calvert, Thomas A. Charlton, Robert N. Ben, Christina L. Addison, Adam Shuhendler. It’s a Trap! Aldolase-Prescribed C4Deoxyradiofluorination Affords Intracellular Trapping and the Tracing of Fructose Metabolism by PET. Journal of Nuclear Medicine, 2024; jnumed.123.266905 DOI: 10.2967/jnumed.123.266905

Share. Facebook Twitter Pinterest LinkedIn Tumblr Email
Biotech Express
  • Website
  • Facebook
  • Twitter
  • LinkedIn

ISSN: 2454-6968 | Biotech Express Magazine publishes articles in the field of biotechnology and allied sciences in a way that have never been presented earlier. It publishes Editorials, Guest Articles, Reports, Interviews, Current News of Govt. Academics and Business, Research Highlights and Notifications of Events, Jobs, Research Proposals in the field of Biotechnology, Biological Sciences, Life Sciences, Microbiology, Biochemistry, Neurosciences, Genetics, Medical Sciences, BioPharma etc.

Related Posts

USFDA approves Biocon Biologics’ biosimilar for Crohn’s disease, psoriasis

Panacea Biotec hits 52-week high after settling patent dispute with Sanofi

IIL launches pediatric dose of India’s 1st Indigenous Hepatitis A vaccine

Leave A Reply Cancel Reply

Current Issue – January 2025
Biotech Express – e-ISSN: 2454-6968

Editorial Board

For Authors – Article Submission and Guidelines

Peer Review Policies

License and Copyright

Advertisement

Recent Posts
  • Special Issue-Exclusive coverage of BRIC-NIAB 15/02/2025
  • India’s Rare Disease updates by Prof. Ramaiah Muthyala 02/01/2025
  • Indian Scientists published positive results of first in nation ‘Hemophilia A’ gene therapy 28/12/2024
  • Unlocking the Potential: Microalgae as a Sustainable Aquafeed Ingredient 27/12/2024
  • Indian scientists developed World’s only farmers’ suit “Kisan Kavach” which can protect them from harmful pesticides 26/12/2024
  • 3 Nobel Prizes in 2024 went to biotech and allied scientists 13/12/2024
  • USFDA approves Biocon Biologics’ biosimilar for Crohn’s disease, psoriasis 01/12/2024
  • Dr. Soumya Swaminathan Honored with FABA Lifetime Achievement Award for Contributions to Global Health 23/11/2024
  • Scientists’ team led by Dr Tapan K Mondal claims Indian tea has independent origin after decoding its first ever Whole Genome 23/11/2024
  • Prof. K C Bansal Elected as a Fellow of The World Academy of Sciences (TWAS) 22/11/2024
Archives
Categories
  • Articles
  • Biotech News
  • Controversial
  • Editorials
  • Events
  • Featured
  • Guest Articles
  • Interviews
  • Interviews – Academia
  • Interviews – Industry
  • News-Industry
  • News-Research
  • Policies
  • SARS- CoV2 & COVID-19 Updates
  • Start-ups
About Us

About Biotech Express

Advisory and Editorial Board

Contact Us

Submission Policy and Guidelines

Submission policies

 

 

Follow us on Social Media
  • Facebook
  • Twitter
  • YouTube
We use cookies to help provide and enhance our service and tailor content and ads. By continuing you agree to the use of cookies. Copyright © 2013-2025 Biotech Express except certain content provided by third parties.

Type above and press Enter to search. Press Esc to cancel.