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You are at:Home»Biotech News»News-Research»New adverse event Genital necrosis with cutaneous thrombosis reported after COVID-19 mRNA vaccination

New adverse event Genital necrosis with cutaneous thrombosis reported after COVID-19 mRNA vaccination

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By Biotech Express on 03/12/2021 News-Research, SARS- CoV2 & COVID-19 Updates
An 84-year-old Japanese woman presented to department with a three-day history of genital necrosis. She had received her first dose of Pfizer–BioNTech BNT162b2 mRNA COVID–19 vaccine 26 days before admission. Nine days after the vaccination, she developed increasing pain in her genital region.
Thrombosis is a rare complication of COVID-19 vaccines that typically affects cerebral and visceral vessels. However, skin involvement is largely unknown. In this paper the authors describe a case of genital necrosis associated with cutaneous thrombosis following COVID-19 vaccination.

Dermatological examination revealed extensive necrosis with surrounding purpura that involved the mons pubis, labia majora, and perineum.

A small but increasing number of thrombotic events have been reported since the launch of mass vaccination campaigns against COVID-19. Adenovirus vector-based vaccines (AstraZeneca and Johnson & Johnson) are associated with severe thrombosis with thrombocytopenia, while mRNA-based vaccines (Pfizer–BioNTech and Moderna) are also associated with some thrombotic events, which do not always accompany thrombocytopenia. The exact pathogenesis remains unknown, but platelet activation is thought to be a key feature underlying these events.

According to authors, to the best of their knowledge, this is the first case of extensive skin necrosis after COVID-19 vaccination that developed outside the injection site.

Source:  https://onlinelibrary.wiley.com/doi/epdf/10.1111/jdv.17837

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